Pituitary stalk transection syndrome

Pituitary stalk transection syndrome, also known as pituitary stalk interruption syndrome, is a syndrome characterised by absent or hypoplastic anterior pituitary gland, thin or absent infundibulum, and ectopic posterior pituitary location.

Patients with pituitary stalk transection usually present in the first decade of life with deficiency of growth hormones resulting in growth retardation 1.

Isolated growth hormone deficiency may progress to multiple pituitary hormones deficiency 2.

Various hypotheses have been proposed to explain the syndrome such as defective migration of the pituitary gland during intra-uterine life or ischemia with subsequent reorganization of the infundibular axons and development of an ectopic posterior pituitary 1.

  • absent/hypoplastic anterior pituitary gland
  • thin or absent infundibulum
  • ectopic posterior pituitary location

Treatment consists of hormonal replacement 3.

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Article Information

rID: 32598
Section: Syndromes
Tag: cases
Synonyms or Alternate Spellings:
  • Pituitary stalk interruption syndrome

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