Pituitary stalk transection syndrome
Pituitary stalk transection syndrome, also known as pituitary stalk interruption syndrome, is a syndrome characterized by absent or hypoplastic anterior pituitary gland, thin or absent infundibulum, and ectopic posterior pituitary location.
Patients with pituitary stalk transection usually present in the first decade of life with deficiency of growth hormones resulting in growth retardation 1.
Isolated growth hormone deficiency may progress to multiple pituitary hormones deficiency 2.
Various hypotheses have been proposed to explain the syndrome such as defective migration of the pituitary gland during intra-uterine life or ischemia with subsequent reorganization of the infundibular axons and development of an ectopic posterior pituitary 1.
- absent/hypoplastic anterior pituitary gland
- thin or absent infundibulum
- ectopic posterior pituitary location
Treatment and prognosis
Treatment consists of hormonal replacement 3.
- 1. Ioachimescu AG, Hamrahian AH, Stevens M et-al. The pituitary stalk transection syndrome: multifaceted presentation in adulthood. Pituitary. 2013;15 (3): 405-11. doi:10.1007/s11102-011-0337-9 - Pubmed citation
- 2. van der Linden AS, van Es HW. Case 112: pituitary stalk transection syndrome with ectopic posterior pituitary gland. Radiology. 2007;243 (2): 594-7. doi:10.1148/radiol.2432040385 - Pubmed citation
- 3. Kulkarni C, Moorthy S, Pullara SK et-al. Pituitary stalk transection syndrome: Comparison of clinico-radiological features in adults and children with review of literature. Indian J Radiol Imaging. 2012;22 (3): 182-5. doi:10.4103/0971-3026.107179 - Free text at pubmed - Pubmed citation