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Citation:
Weerakkody Y, Plasma cell leukemia. Reference article, Radiopaedia.org (Accessed on 15 Jan 2025) https://doi.org/10.53347/rID-73428
Plasma cell leukemia (PCL) is a rare and aggressive form of leukemia and plasma cell dyscrasia. It can be divided into primary (pPCL) and secondary (sPCL) following previously diagnosed multiple myeloma. It is also considered clinically and genetically distinct from multiple myeloma.
Plasma cell leukemia is defined by the observation in blood of more than 20% clonal plasma cells by differential count of the leukocytes or by counting more than 2 × 109 per liter circulating clonal plasma cells.
At time of writing (2020) it is thought to have a fulminant course and poor prognosis.
See also
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1 .Jelinek T, Kryukov F, Rihova L, Hajek R. Plasma cell leukemia: from biology to treatment. (2015) European journal of haematology. 95 (1): 16-26. doi:10.1111/ejh.12533 - Pubmed
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2 .Gundesen MT, Lund T, Moeller HEH, Abildgaard N. Plasma Cell Leukemia: Definition, Presentation, and Treatment. (2019) Current oncology reports. 21 (1): 8. doi:10.1007/s11912-019-0754-x - Pubmed
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3 .Fernández de Larrea C, Kyle RA, Durie BG, Ludwig H, Usmani S, Vesole DH, Hajek R, San Miguel JF, Sezer O, Sonneveld P, Kumar SK, Mahindra A, Comenzo R, Palumbo A, Mazumber A, Anderson KC, Richardson PG, Badros AZ, Caers J, Cavo M, LeLeu X, Dimopoulos MA, Chim CS, Schots R, Noeul A, Fantl D, Mellqvist UH, Landgren O, Chanan-Khan A, Moreau P, Fonseca R, Merlini G, Lahuerta JJ, Bladé J, Orlowski RZ, Shah JJ. Plasma cell leukemia: consensus statement on diagnostic requirements, response criteria and treatment recommendations by the International Myeloma Working Group. (2013) Leukemia. 27 (4): 780-91. doi:10.1038/leu.2012.336 - Pubmed
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4. Hayman SR, Fonseca R. Plasma cell leukemia. (2001) Current treatment options in oncology. 2 (3): 205-16. doi:10.1007/s11864-001-0034-4 - Pubmed
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