Plasma cell mastitis
Citation, DOI & article data
Plasma cell mastitis is a benign breast condition that represents calcification of inspissated secretions in or immediately adjacent to ectatic benign ducts. It is clinically relevant since it shares some clinical, microscopical and macroscopical similarities with breast cancer 5.
It is typically seen in nonpregnant and non-lactating females 6.
It is thought to represent aseptic inflammation with infiltration of plasma cells and lymphocytes in the breast tissue from the extravasation of intraductal secretions into periductal connective tissue 5.
Plasma cell mastitis has a characteristic appearance. Calcifications are thick, linear, rod-like or cigar-shaped. Calcifications can be up to 10 mm long. They tend to be bilateral, often symmetrical in distribution and oriented with long axes pointing toward the nipple1. Branching may sometimes be seen.
Treatment and prognosis
It is a benign entity and there is no increased risk of malignancy 3.
- 1. Sickles EA. Breast calcifications: mammographic evaluation. Radiology. 1986;160 (2): 289-93. Radiology (abstract) - Pubmed citation
- 2. Rosen PP. Rosen's breast pathology. Lippincott Williams & Wilkins. (2001) ISBN:0781723795. Read it at Google Books - Find it at Amazon
- 3. Fischer U, Baum F, Luftner-Nagel S. Breast imaging. Thieme Publishing Group. (2008) ISBN:3131451211. Read it at Google Books - Find it at Amazon
- 4. Paredes ES. Atlas of mammography. Lippincott Williams & Wilkins. (2007) ISBN:0781764335. Read it at Google Books - Find it at Amazon
- 5. Katic V, Stosic D, Rankovic A, Simonovic M, Todorovic J, Mladenovic M, Jovic A, Stojanovic M. Plasma Cell Mastitis Resembling a Breast Cancer: A Case Report and Review of the Literature. (2017) Journal of Infectious Diseases & Therapy. 5 (6): 1. doi:10.4172/2332-0877.1000346
- 6. Rong Chen, Baoquan Hu, Yulong Zhang, Caibao Liu, Lianhua Zhao, Yan Jiang, Yan Xu. Differential diagnosis of plasma cell mastitis and invasive ductal carcinoma using multiparametric MRI. (2020) Gland Surgery. 9 (2): 27890. doi:10.21037/gs.2020.03.30