Plasma cell mastitis

Dr Adam Eid Ramsey and Radswiki et al.

Plasma cell mastitis is a benign breast condition which represents calcification of inspissated secretions in or immediately adjacent to ectatic benign ducts. 

It is typically seen in older women (e.g. >60 years of age).

It is thought to represent aseptic inflammation of the breast from extravasation of intraductal secretions into periductal connective tissue. 

Plasma cell mastitis has a characteristic appearance. Calcifications are thick, linear, rod-like or cigar-shaped. Calcifications can be up to 10 mm long. They tend to be bilateral, often symmetrical in distribution and orientated with long axes pointing toward the nipple1. Branching may sometimes be seen. 

Compared to microcalcifications of DCIS or ductal carcinoma, calcifications of plasma cell mastitis are larger in both length and calibre and have a smoother outline. 

It is a benign entity and there is no increased risk of malignancy 3.

Breast imaging and pathology
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Article information

rID: 12476
System: Breast
Synonyms or Alternate Spellings:
  • Secretory disease of the breast
  • Secreatory breast disease

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Cases and figures

  • Case 1
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  • Case 2: with associated fibroadenomas
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  • Case 3
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