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Citation:
Weerakkody Y, Hocking J, Plasmablastic lymphoma. Reference article, Radiopaedia.org (Accessed on 19 Apr 2024) https://doi.org/10.53347/rID-79688
Plasmablastic lymphoma (PbL) is a type of rare and aggressive B-cell malignancy (considered a type of non-Hodgkin lymphoma).
It usually comprises of large neoplastic cells, most of them resembling plasmablasts that have a CD20-negative phenotype.
Associations
Although initially described as being associated with HIV, over the years it has also been identified in patients with solid organ transplant and immunocompetent patients.
It is generally also associated with Epstein-Barr virus and HHV-8 infections and frequently involves the oral cavity 6.
Treatment and prognosis
It usually has an aggressive behavior and is refractory to chemotherapy with a poor prognosis in many patients.
History and etymology
It was first described in 1997 by Delecluse et al in patients with HIV.
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4. Degnan AJ, Levy LM. Orbital plasmablastic lymphoma with remission following chemotherapy. (2011) Journal of radiology case reports. 5 (2): 1-7. doi:10.3941/jrcr.v5i2.617 - Pubmed
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5. Moramarco A, Marenco M, La Cava M, Lambiase A. Radiological-Pathological Correlation in Plasmablastic Lymphoma in an Immunocompromised Patient. (2018) Case reports in ophthalmological medicine. 2018: 4746050. doi:10.1155/2018/4746050 - Pubmed
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6. Javadi S, Menias C, Karbasian N et al. HIV-Related Malignancies and Mimics: Imaging Findings and Management. Radiographics. 2018;38(7):2051-68. doi:10.1148/rg.2018180149 - Pubmed
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7. Han X, Duan M, Hu L, Zhou D, Zhang W. Plasmablastic Lymphoma. Medicine. 2017;96(9):e5981. doi:10.1097/md.0000000000005981 - Pubmed
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