Pleural synovial sarcoma

Last revised by Dr Bruno Di Muzio on 30 Apr 2020

Pleural synovial sarcoma is a rare tumor and refers to a primary synovial sarcoma arising from the pleura. It together with primary synovial sarcoma of the lung comes under the broader category of pleuro-pulmonary synovial sarcomas.

They are thought to comprise <1% of all primary lung malignancies 4. They typically occur in adolescents and young adults (between the ages of 15 and 40 years). 

Their histological characteristics may be mistaken for those of malignant mesothelioma or other spindle cell tumors. Historically they are believed to originate from primitive pluripotent mesenchyme capable of synovial differentiation.

The presence of BCL-2 protein may be a helpful marker in distinguishing synovial sarcoma from mesothelioma.

Consider other pleural based tumors such as:

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Cases and figures

  • Figure 1: histology
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  • Case 1
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  • Case 2
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