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Citation:
Weerakkody Y, Di Muzio B, Pleural synovial sarcoma. Reference article, Radiopaedia.org (Accessed on 24 Mar 2025) https://doi.org/10.53347/rID-40889
Pleural synovial sarcoma is a rare tumor and refers to a primary synovial sarcoma arising from the pleura. It together with primary synovial sarcoma of the lung comes under the broader category of pleuro-pulmonary synovial sarcomas.
They are thought to comprise <1% of all primary lung malignancies 4. They typically occur in adolescents and young adults (between the ages of 15 and 40 years).
Their histological characteristics may be mistaken for those of malignant mesothelioma or other spindle cell tumors. Historically they are believed to originate from primitive pluripotent mesenchyme capable of synovial differentiation.
Markers
The presence of BCL-2 protein may be a helpful marker in distinguishing synovial sarcoma from mesothelioma.
Consider other pleural based tumors such as:
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2. Frazier AA, Franks TJ, Pugatch RD et-al. From the archives of the AFIP: Pleuropulmonary synovial sarcoma. Radiographics. 2006;26 (3): 923-40. doi:10.1148/rg.263055211 - Pubmed citation
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3. Nicholson AG, Goldstraw P, Fisher C. Synovial sarcoma of the pleura and its differentiation from other primary pleural tumours: a clinicopathological and immunohistochemical review of three cases. Histopathology. 1999;33 (6): 508-13. Pubmed citation
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4. Loscertales J, Triviño A, Gallardo G et-al. Primary monophasic synovial sarcoma of the pleura: diagnosis and treatment. Interact Cardiovasc Thorac Surg. 2011;12 (5): 885-7. doi:10.1510/icvts.2010.259531 - Pubmed citation
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5. Srinivasan L, Bhat R, Patil S et-al. Chest. 2010;138 (4 MeetingAbstracts): . doi:10.1378/chest.11086
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