Pleurodesis
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- updated 12 Apr 2022:
Nothing to disclose
Updates to Article Attributes
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was changed:
Pleurodesis is a procedure that involves the administration of an agent into the pleural space to cause adhesion to the chest wall (usually from adhesion between the parietal and the visceral layers of the pleura). Usually an irritative chemical agent (chemical pleurodesis) and rarely microbiological and mechanical methods are used.
Indication
It can be used in a number of situation including:
- development of chronic/recurrent pneumothoraces
- development of chronic/recurrent pleural effusions
Agents
Various agents have been used which include:
- talc - talc pleurodesis
- one of the most commonly used
- usually around 2.5-10 mg
- general anaesthesia required if instilled by powder; anecdotal reports of pneumonitis and acute respiratory distress syndrome (ARDS)
- tetracycline class antibiotics
- minocycline
- usually around (300 mg)
- doxycycline
- tends to requires multiple doses
- tetracycline
- minocycline
- Corynebacterium parvum - Corynebacterium parvum pleurodesis
- mepacrine
- bleomycin
- povidone-iodine
- quinacrine hydrochloride (Atabrine)
-<p><strong>Pleurodesis</strong> is a procedure that involves the administration of an agent into the <a href="/articles/pleural-space">pleural space</a> to cause adhesion to the chest wall (usually from adhesion between the parietal and the visceral layers of the pleura). Usually an irritative chemical agent (<a href="/articles/chemical-pleurodesis">chemical pleurodesis</a>) and rarely microbiological and mechanical methods are used.</p><h4>Indication</h4><p>It can be used in a number of situation including:</p><ul>-<li>development of chronic/recurrent pneumothoraces</li>-<li>development of chronic/recurrent pleural effusions</li>-</ul><h4>Agents</h4><p>Various agents have been used which include:</p><ul>-<li>talc - <a href="/articles/talc-pleurodesis">talc pleurodesis</a><ul>-<li>one of the most commonly used</li>-<li>usually around 2.5-10 mg</li>-<li>general anaesthesia required if instilled by powder; anecdotal reports of pneumonitis and <a title="acute respiratory distress syndrome (ARDS)" href="/articles/acute-respiratory-distress-syndrome-1">acute respiratory distress syndrome (ARDS)</a>-</li>-</ul>-</li>-<li>tetracycline class antibiotics<ul>-<li>minocycline<ul><li>usually around (300 mg)</li></ul>-</li>-<li>doxycycline<ul><li>tends to requires multiple doses</li></ul>-</li>-<li>tetracycline</li>-</ul>-</li>-<li>-<em>Corynebacterium parvum - <a href="/articles/corynebacterium-parvum-pleurodesis">Corynebacterium parvum</a></em><a href="/articles/corynebacterium-parvum-pleurodesis"> pleurodesis</a>-</li>-<li>mepacrine</li>-<li>bleomycin</li>-<li>povidone-iodine</li>-<li>quinacrine hydrochloride (Atabrine)</li>- +<p><strong>Pleurodesis</strong> is a procedure that involves the administration of an agent into the <a href="/articles/pleural-space">pleural space</a> to cause adhesion to the chest wall (usually from adhesion between the parietal and the visceral layers of the pleura). Usually an irritative chemical agent (<a href="/articles/chemical-pleurodesis">chemical pleurodesis</a>) and rarely microbiological and mechanical methods are used.</p><h4>Indication</h4><p>It can be used in a number of situation including:</p><ul>
- +<li>development of chronic/recurrent pneumothoraces</li>
- +<li>development of chronic/recurrent pleural effusions</li>
- +</ul><h4>Agents</h4><p>Various agents have been used which include:</p><ul>
- +<li>talc - <a href="/articles/talc-pleurodesis">talc pleurodesis</a><ul>
- +<li>one of the most commonly used</li>
- +<li>usually around 2.5-10 mg</li>
- +<li>general anaesthesia required if instilled by powder; anecdotal reports of pneumonitis and <a title="acute respiratory distress syndrome (ARDS)" href="/articles/acute-respiratory-distress-syndrome-1">acute respiratory distress syndrome (ARDS)</a>
- +</li>
- +</ul>
- +</li>
- +<li>tetracycline class antibiotics<ul>
- +<li>minocycline<ul><li>usually around (300 mg)</li></ul>
- +</li>
- +<li>doxycycline<ul><li>tends to requires multiple doses</li></ul>
- +</li>
- +<li>tetracycline</li>
- +</ul>
- +</li>
- +<li>
- +<em>Corynebacterium parvum - <a href="/articles/corynebacterium-parvum-pleurodesis">Corynebacterium parvum</a></em><a href="/articles/corynebacterium-parvum-pleurodesis"> pleurodesis</a>
- +</li>
- +<li>mepacrine</li>
- +<li>bleomycin</li>
- +<li>povidone-iodine</li>
- +<li>quinacrine hydrochloride (Atabrine)</li>
References changed:
- 1. Sonoda A, Jeudy J, White C et al. Pleurodesis: Indications and Radiologic Appearance. Jpn J Radiol. 2015;33(5):241-5. <a href="https://doi.org/10.1007/s11604-015-0412-7">doi:10.1007/s11604-015-0412-7</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/25791777">Pubmed</a>
- 2. McLoud T, Isler R, Head J. The Radiologic Appearance of Chemical Pleurodesis. Radiology. 1980;135(2):313-7. <a href="https://doi.org/10.1148/radiology.135.2.7367618">doi:10.1148/radiology.135.2.7367618</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/7367618">Pubmed</a>
- 3. Rodriguez-Panadero F & Montes-Worboys A. Mechanisms of Pleurodesis. Respiration. 2012;83(2):91-8. <a href="https://doi.org/10.1159/000335419">doi:10.1159/000335419</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/22286268">Pubmed</a>
- 1. Sonoda A, Jeudy J, White CS, Kligerman SJ, Nitta N, Lempel J, Frazier AA. Pleurodesis: indications and radiologic appearance. (2015) Japanese journal of radiology. 33 (5): 241-5. <a href="https://doi.org/10.1007/s11604-015-0412-7">doi:10.1007/s11604-015-0412-7</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/25791777">Pubmed</a> <span class="ref_v4"></span>
- 2. T C McLoud, R Isler, J Head. The radiologic appearance of chemical pleurodesis. (1980) Radiology. <a href="https://doi.org/10.1148/radiology.135.2.7367618">doi:10.1148/radiology.135.2.7367618</a> <span class="ref_v4"></span>
- 3. Rodriguez-Panadero F, Montes-Worboys A. Mechanisms of pleurodesis. (2012) Respiration; international review of thoracic diseases. 83 (2): 91-8. <a href="https://doi.org/10.1159/000335419">doi:10.1159/000335419</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/22286268">Pubmed</a> <span class="ref_v4"></span>
Tags changed:
- cases