Last revised by Calum Worsley on 14 Oct 2022

Pleurodesis is a procedure that involves the administration of an agent into the pleural space to cause adhesion to the chest wall (usually from adhesion between the parietal and the visceral layers of the pleura). Usually an irritative chemical agent (chemical pleurodesis) and rarely microbiological and mechanical methods are used.


It can be used in a number of situation including:

  • development of chronic/recurrent pneumothoraces
  • development of chronic/recurrent pleural effusions


Various agents have been used which include:

  • talc - talc pleurodesis
  • tetracycline class antibiotics
    • minocycline
      • usually around (300 mg)
    • doxycycline
      • tends to requires multiple doses
    • tetracycline
  • Corynebacterium parvum - Corynebacterium parvum pleurodesis
  • mepacrine
  • bleomycin
  • povidone-iodine
  • quinacrine hydrochloride (Atabrine)

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