Polyposis syndromes

The polyposis syndromes are disorders in which more than 100 gastrointestinal polyps are present throughout the GI tract:

• hereditary
  • hereditary nonpolyposis colorectal cancer
  • familial adenomatous polyposis syndrome (FAPS)
    • classic FAP
    • Gardner syndrome 
    • Turcot syndrome
  • Bannayan–Riley–Ruvalcaba syndrome
  • Cowden syndrome 
  • Peutz-Jeghers syndrome
  • tuberous sclerosis
  • juvenile polyposis syndrome *
• non-hereditary
  • serrated polyposis syndrome (SPS), also known as hyperplastic polyposis syndrome
  • Cronkhite-Canada syndrome
  • juvenile polyposis syndrome *

* approximately 25% cases of juvenile polyposis syndrome are familial with AD inheritance and 75% non-hereditary ⁴

Polyposis syndromes can also be classified into those with predominantly adenomatous polyps and those with hamartomatous polyps:

• adenomatous
  • familial adenomatous polyposis syndrome (FAPS)
  • Gardner syndrome 
  • attenuated FAP
  • MYH syndrome
• hamartomatous
  • juvenile polyposis syndrome
  • Bannayan–Riley–Ruvalcaba syndrome
  • Cowden syndrome 
  • Peutz-Jeghers syndrome
  • Cronkhite-Canada syndrome
• mixed
  • hereditary mixed polyposis syndrome