Postobstructive pulmonary edema

Last revised by Ashesh Ishwarlal Ranchod on 8 Apr 2023

Postobstructive pulmonary edema is a type of non-cardiogenic pulmonary edema and is an uncommon but well-described complication of upper airway obstruction.

It occurs in three clinical settings 6:

  • acute airway obstruction
  • chronic upper airway obstruction
  • immediately after the relief of acute upper airway obstruction

Two different mechanisms have been proposed for the development of pulmonary edema in the setting of upper airway obstruction 1:

  • significant fluid shifts due to changes in intrathoracic pressure creating a hydrostatic transpulmonary gradient with fluid moving from high pressure (pulmonary venous system) to low pressure (pulmonary interstitium and airspaces)
  • disruption of the alveolar epithelial and pulmonary microvascular membranes from severe mechanical stress, leading to increased pulmonary capillary permeability and protein-rich pulmonary edema

The most common cause of post-obstructive pulmonary edema is laryngospasm during intubation or after anesthesia in the postoperative period.

Patients in whom post-obstructive pulmonary edema develops generally have an uncomplicated hospital course with rapid resolution 1.

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