Pregnancy-associated plasma protein-A
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At the time the article was created Henry Knipe had no recorded disclosures.
View Henry Knipe's current disclosuresAt the time the article was last revised Daniel J Bell had no recorded disclosures.
View Daniel J Bell's current disclosures- Pregnancy-associated plasma protein-A (PAPP-A)
- PAPPA
- PAPP-A
Pregnancy-associated plasma protein-A (PAPP-A) is a protein found in the maternal circulation and is produced by the placenta. The PAPP-A gene has been assigned to human chromosome 9q33.1 and contains 22 exons 5. PAPP-A values tend to rise exponentially during pregnancy and the reference range depends on the stage of gestation. The common practice is to use the unit multiple of median (MoM) as a gestational age-dependent expression of PAPP-A concentration.
Low maternal serum PAPP-A levels in the first trimester have been associated with a wide range of fetal pathology and pregnancy-related complications 1-4:
References
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- 2. Smith GC, Stenhouse EJ, Crossley JA et-al. Early pregnancy levels of pregnancy-associated plasma protein a and the risk of intrauterine growth restriction, premature birth, preeclampsia, and stillbirth. J. Clin. Endocrinol. Metab. 2002;87 (4): 1762-7. doi:10.1210/jcem.87.4.8430 - Pubmed citation
- 3. Clinical Radiology: The Essentials. LWW. ISBN:1451142501. Read it at Google Books - Find it at Amazon
- 4. Ong CY, Liao AW, Spencer K et-al. First trimester maternal serum free beta human chorionic gonadotrophin and pregnancy associated plasma protein A as predictors of pregnancy complications. BJOG. 2000;107 (10): 1265-70. Pubmed citation
- 5. Shiefa S, Amargandhi M, Bhupendra J et-al. First Trimester Maternal Serum Screening Using Biochemical Markers PAPP-A and Free β-hCG for Down Syndrome, Patau Syndrome and Edward Syndrome. Indian J Clin Biochem. 2013;28 (1): 3-12. doi:10.1007/s12291-012-0269-9 - Free text at pubmed - Pubmed citation
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