Pregnancy-associated plasma protein-A
Updates to Synonym Attributes
Updates to Article Attributes
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was changed:
Pregnancy-associated plasma protein-A (PAPP-A) is a protein found in the maternal circulation and is produced by the placenta. The PAPP-A gene has been assigned to human chromosome 9q33.1 and contains 22 exons 5. PAPP-A values tend to rise exponentially during pregnancy and the reference range depends on the stage of gestation. The common practice is to use the unit multiple of median (MoM) as a gestational age-dependent expression of PAPP-A concentration.
Low maternal serum PAPP-A levels in the first trimester have been associated with a wide range of fetal pathology and pregnancy related complications 1-4:
-<p><strong>Pregnancy-associated plasma protein-A</strong> (<strong>PAPP-A</strong>) is a protein found in the maternal circulation and is produced by the <a href="/articles/placenta">placenta</a>. </p><p>Low maternal serum PAPP-A levels in the <a href="/articles/first-trimester">first trimester</a> have been associated with a wide range of fetal pathology and pregnancy related complications <sup>1-4</sup>:</p><ul>- +<p><strong>Pregnancy-associated plasma protein-A</strong> (<strong>PAPP-A</strong>) is a protein found in the maternal circulation and is produced by the <a href="/articles/placenta">placenta</a>. The PAPP-A gene has been assigned to human chromosome 9q33.1 and contains 22 exons <sup>5</sup>. PAPP-A values tend to rise exponentially during pregnancy and the reference range depends on the stage of gestation. The common practice is to use the unit multiple of median (MoM) as a gestational age-dependent expression of PAPP-A concentration.</p><p>Low maternal serum PAPP-A levels in the <a href="/articles/first-trimester">first trimester</a> have been associated with a wide range of fetal pathology and pregnancy related complications <sup>1-4</sup>:</p><ul>
-<li>pregnancy-induced hypertension</li>- +<li><a title="pregnancy-induced hypertension" href="/articles/pregnancy-induced-hypertension">pregnancy-induced hypertension</a></li>
-<li>gestational diabetes mellitus</li>- +<li><a title="gestational diabetes mellitus" href="/articles/gestational-diabetes-mellitus">gestational diabetes mellitus</a></li>
References changed:
- 5. Shiefa S, Amargandhi M, Bhupendra J et-al. First Trimester Maternal Serum Screening Using Biochemical Markers PAPP-A and Free β-hCG for Down Syndrome, Patau Syndrome and Edward Syndrome. Indian J Clin Biochem. 2013;28 (1): 3-12. <a href="http://dx.doi.org/10.1007/s12291-012-0269-9">doi:10.1007/s12291-012-0269-9</a> - <a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547446">Free text at pubmed</a> - <a href="http://www.ncbi.nlm.nih.gov/pubmed/24381414">Pubmed citation</a><span class="auto"></span>