Primary hypogammaglobulinemia

Primary hypogammaglobulinemia is a congenital/non-acquired form of hypogammaglobulinaemia and can be of heterogeneous aetiology.

The condition is characterised by low levels of serum immunoglobulins and impaired antibody responses.

The majority of cases of primary hypogammaglobulinemia are represented by 

• common variable immunodeficiency (CVID) and
• X-linked agammaglobulinemia (XLA)

See also

• primary immunodeficiency states