Primary lateral sclerosis

Last revised by Dr Francis Deng on 17 Apr 2022

Primary lateral sclerosis (PLS) is a form of motor neuron disease (MND)

Clinical presentation

Diagnosis

The diagnosis is clinical, after exclusion of structural, neurodegenerative and metabolic mimics.

Pathology

It is characterized by a slowly progressive upper motor neuron syndrome.

Radiographic features

MRI

MRI shows prominent precentral gyrus atrophy and T2/FLAIR hyperintensity in the corticospinal tracts in the brain and spinal cord 3.

Differential diagnosis

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