Primary lateral sclerosis

Primary lateral sclerosis (PLS) is a form of motor neuron disease (MND)

Clinical presentation


The diagnosis is clinical, after exclusion of structural, neurodegenerative and metabolic mimics.


It is characterized by a slowly progressive upper motor neuron syndrome.

Differential diagnosis

Article information

rID: 76761
Synonyms or Alternate Spellings:
  • Primary lateral sclerosis (PLS)

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