Primary lateral sclerosis

Last revised by Francis Deng on 17 Apr 2022

Primary lateral sclerosis (PLS) is a form of motor neuron disease (MND)

Clinical presentation


The diagnosis is clinical, after exclusion of structural, neurodegenerative and metabolic mimics.


It is characterized by a slowly progressive upper motor neuron syndrome.

Radiographic features


MRI shows prominent precentral gyrus atrophy and T2/FLAIR hyperintensity in the corticospinal tracts in the brain and spinal cord 3.

Differential diagnosis

ADVERTISEMENT: Supporters see fewer/no ads

Updating… Please wait.

 Unable to process the form. Check for errors and try again.

 Thank you for updating your details.