Primary osteosarcoma (breast)
Citation, DOI, disclosures and article data
At the time the article was created Yuranga Weerakkody had no recorded disclosures.
View Yuranga Weerakkody's current disclosuresAt the time the article was last revised Daniel J Bell had no recorded disclosures.
View Daniel J Bell's current disclosures- Extra skeletal osteosarcoma of breast
- Primary osteosarcoma of breast
- Extra skeletal osteosarcoma of the breast
- Osteosarcoma of breast
- Primary breast osteosarcoma
- Primary pure osteosarcoma of the breast
- Extraskeletal osteosarcoma of breast
Primary osteosarcoma of the breast, a.k.a. extraskeletal osteosarcoma of breast, is an uncommon breast malignancy and is a subtype of extraskeletal osteosarcoma.
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Epidemiology
While it can present in a wide are group, the peak age at presentation is around the 6th decade 7.
Pathology
The presence of bone in breast lesions is not diagnostic of osteosarcoma as osteoid tissue can be present in epithelial and mesenchymal neoplasms, both benign and malignant, such as fibroadenoma, phyllodes tumor 13, and metaplastic carcinomas. Therefore, a diagnosis of mammary osteosarcoma can only be established after a metaplastic carcinoma or biphasic tumor has been adequately excluded. Approximately 60% of tumors are grossly circumscribed 7.
Markers
Serum alkaline phosphate (ALP) levels are typically elevated.
Radiographic features
Mammography
Mammographic appearances can be variable. Most of the tumors presented as large masses with relatively well-defined margins and lobulated borders, often containing calcifications. Calcifications tend to be usually coarse (cotton wool like), dense, and sometimes similar to fibroadenomas.
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Treatment and prognosis
Mammary osteosarcomas are aggressive tumors with a propensity for blood-borne rather than lymphatic spread. A total excision without an axillary dissection is usually part of standard treatment.
See also
References
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- 2. Brown AL, Holwill SD, Thomas VA et-al. Case report: Primary osteosarcoma of the breast: imaging and histological features. Clin Radiol. 1998;53 (12): 920-2. - Pubmed citation
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- 6. Watt AC, Haggar AM, Krasicky GA. Extraosseous osteogenic sarcoma of the breast: mammographic and pathologic findings. Radiology. 1984;150 (1): 34. Radiology (abstract) - Pubmed citation
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- 8. Ogundiran TO, Ademola SA, Oluwatosin OM et-al. Primary osteogenic sarcoma of the breast. World J Surg Oncol. 2006;4 : 90. doi:10.1186/1477-7819-4-90 - Free text at pubmed - Pubmed citation
- 9. Nugent E, Wang LM, Mccormack O et-al. Pure primary osteosarcoma of the breast. Breast J. 17 (4): 425-6. doi:10.1111/j.1524-4741.2011.01093.x - Pubmed citation
- 10. Vanhoeij M, Bourgain C, Lamote J. Primary osteogenic sarcoma of the breast: a rare and fatal case. Breast J. 17 (1): 97-9. doi:10.1111/j.1524-4741.2010.01029.x - Pubmed citation
- 11. Fiori E, Burza A, Izzo L et-al. Primary osteosarcoma of the breast. Breast J. 16 (6): 656-8. doi:10.1111/j.1524-4741.2010.01008.x - Pubmed citation
- 12. Murakami S, Isozaki H, Shou T et-al. Primary osteosarcoma of the breast. Pathol. Int. 2009;59 (2): 111-5. doi:10.1111/j.1440-1827.2008.02338.x - Pubmed citation
- 13. Matsuo K, Fukutomi T, Tsuda H et-al. A case of malignant phyllodes tumor of the breast with osteosarcomatous features. Breast Cancer. 2001;8 (1): 79-83. - Pubmed citation
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