Primary pulmonary choriocarcinoma

Primary pulmonary choriocarcinoma (PPC) is a type of non gestational choriocarcinoma which originates in the lung. It is an extremly rare entity.

Presentation can be variable ranging from dyspnea, cough and chest pain, to weight loss. Some patients may present with hemoptysis. On occasion it may be routinely discovered as an incidental lung mass / lesion 5.

Serum beta HCG levels tend to be elevated - and may drop following resection and therapy 6.

In contrast to gestational choriocarcinoma, primary pulmonary choriocarcinomas are considered generally unresponsive to surgical and chemotherapeutic treatment and are thought to carry a much poorer prognosis (with 5 year survival being under 5%). At the time of initial writing, resection followed by adjuvant chemotherapy is considered to the most effective 1.

When  a suspected lung lesion shows "choriocarcinoma" on histology following biospy - the main differential consideration is metastatic choriocarcinoma to lung.

Article information

rID: 20560
System: Chest
Tag: cases
Synonyms or Alternate Spellings:
  • Primary pulmonary choriocarcinoma (PPC)
  • Primary pulmonary choriocarcinomas
  • Primary choriocarcinoma of the lung
  • Primary lung choriocarcinomas
  • Primary lung choriocarcinoma
  • Primary choriocarcinoma of lung

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