Pulmonary enteric adenocarcinoma (PEAC) or pulmonary adenocarcinoma with enteric differentiation (PAED) is an extremely rare variant of primary invasive adenocarcinoma of the lung. It has morphological and immunohistochemical profiles overlapping with that of colorectal carcinoma. Due to this it is is difficult to diagnose and requires definite exclusion of a colonic primary.
It is usually defined as a primary pulmonary adenocarcinoma where the enteric component exceeds 50% and with expression of at least 1 immunohistochemical marker of enteric differentiation.
- 1. Wang CX, Liu B, Wang YF, Zhang RS, Yu B, Lu ZF, Shi QL, Zhou XJ. Pulmonary enteric adenocarcinoma: a study of the clinicopathologic and molecular status of nine cases. (2014) International journal of clinical and experimental pathology. 7 (3): 1266-74. Pubmed
- 2. Li HC, Schmidt L, Greenson JK, Chang AC, Myers JL. Primary pulmonary adenocarcinoma with intestinal differentiation mimicking metastatic colorectal carcinoma: case report and review of literature. (2009) American journal of clinical pathology. 131 (1): 129-33. doi:10.1309/AJCPB04XWICTFERL - Pubmed
- 3. Hatanaka K, Tsuta K, Watanabe K, Sugino K, Uekusa T. Primary pulmonary adenocarcinoma with enteric differentiation resembling metastatic colorectal carcinoma: a report of the second case negative for cytokeratin 7. (2011) Pathology, research and practice. 207 (3): 188-91. doi:10.1016/j.prp.2010.07.005 - Pubmed
- 4. Nottegar A, Tabbò F, Luchini C, Brunelli M, Bria E, Veronese N, Santo A, Cingarlini S, Gilioli E, Ogliosi C, Eccher A, Montagna L, Pedron S, Doglioni C, Cangi MG, Inghirami G, Chilosi M. Pulmonary Adenocarcinoma With Enteric Differentiation: Immunohistochemistry and Molecular Morphology. (2018) Applied immunohistochemistry & molecular morphology : AIMM. 26 (6): 383-387. doi:10.1097/PAI.0000000000000440 - Pubmed