Programmed death-ligand 1 (PD-L1)-targeted monoclonal antibodies

Programmed death-ligand 1 (PD-L1)-targeted monoclonal antibodies interact with a protein called PD-1 on T-cells and can be useful in determining if certain immunomodulation therapies can be used in treatment of certain types of cancers. PD-L1 is a major immune checkpoint protein that mediates antitumor immune suppression and response. 

Imaging applications

Nuclear medicine
PET

Some studies show that agents, such as the peptide-based imaging agent, gallium-68-WL12 can be used to detect PD-L1 expression in tumors non-invasively by positron emission tomography (PET) 5

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Article information

rID: 69103
System: Chest
Section: Pathology
Synonyms or Alternate Spellings:
  • PD L1
  • PD L1 antibody

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