Progressive multifocal leukoencephalopathy immune reconstitution inflammatory syndrome
Progressive multifocal leukoencephalopathy immune reconstitution inflammatory syndrome (PML-IRIS) is a form of immune reconstitution inflammatory syndrome (IRIS) seen in patients who are immunomodulated and develop an aggressive form of progressive multifocal leukoencephalopathy (PML).
Two types of PML-IRIS are recognised:
- PML-s-IRIS: simultaneous development of IRIS and PML due to immune reconstitution
- PML-d-IRIS: immune reconstitution worsens preexisting PML
- 1. Tan K, Roda R, Ostrow L, McArthur J, Nath A. PML-IRIS in patients with HIV infection: clinical manifestations and treatment with steroids. Neurology. 72 (17): 1458-64. doi:10.1212/01.wnl.0000343510.08643.74 - Pubmed
- 2. Gheuens S, Smith DR, Wang X, Alsop DC, Lenkinski RE, Koralnik IJ. Simultaneous PML-IRIS after discontinuation of natalizumab in a patient with MS. Neurology. 78 (18): 1390-3. doi:10.1212/WNL.0b013e318253d61e - Pubmed