Prostate cancer (summary)

Dr Jeremy Jones et al.

Prostate cancer, also called carcinoma of the prostate or prostate carcinoma, is the commonest malignant tumour in men. It is primarily a disease of old age and many men remain asymptomatic. 

Reference article

This is a summary article; read more in our article on prostate cancer.

  • epidemiology
    • primarily a disease of the elderly
  • presentation
    • elevated PSA without clinical symptoms
    • large prostate on rectal examination
    • urinary symptoms
    • back pain
  • pathophysiology
    • 95% prostatic adenocarcinoma
    • spread
      • local invasion
      • lymphatic spread
      • haematogenous spread
        • bone (90%)
    • use Gleason score
  • investigation
    • ultrasound-assisted prostatic biopsy
    • local and whole-body staging
  • treatment
    • depends on whether there is spread and if the patient is symptomatic
    • options include
      • radical prostatectomy
      • brachytherapy (insertion of radioactive rods into the prostate)
      • external beam radiotherapy
  • assist in a successful biopsy
  • MR for local staging, e.g. is there extracapsular spread?
  • whole-body staging
  • a hypoechoic region in the periphery of the gland
  • ultrasound-guided transrectal biopsy
  • used for local staging
  • determine whether tumour extends out with the prostatic capsule
  • can be used to guide biopsy if the US-guided biopsy is negative
  • not useful for detection of in situ prostatic cancer
  • can be useful to detect enlarged lymph nodes
  • used for identifying distant bone metastases
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Article information

rID: 49849
System: Urogenital
Synonyms or Alternate Spellings:

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Cases and figures

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    Case 1: T3 prostate cancer
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    Case 2: prostate carcinoma
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    Osteoblastic meta...
    Case 3: osteoblastic metastases (prostate carcinoma)
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