PSA density

The PSA density (PSAD), is a calculation performed at diagnosis and is the serum PSA level (ng/mL) divided by the volume of the prostate gland (mL)1. Prostate volume is calculated from TRUS measurements2,3

Alternatively, PSAD may be calculated using MRI measurements3 of prostate volumes or less commonly, using post-surgical histopathological measurements of prostate volumes4

PSAD has been used as a prognostication tool in helping decide between a watch-and-wait or an invasive approach when managing prostate carcinoma 5. The cut-off used most commonly is 0.15 or 0.20 ng/mL2.

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