Pseudocirrhosis is a term used to recapitulate imaging findings of cirrhosis, but occurring in the setting of hepatic metastases. It is most commonly reported following chemotherapeutic treatment of breast cancer metastases, although has also been reported prior to treatment, and with other malignancies 5.

The term "pseudocirrhosis" is intended to convey a different disease process compared with cirrhosis of chronic liver disease, but there may be similarities in presentation, including liver failure, ascites, varices, and other findings of portal hypertension

Two pathophysiologic correlates of pseudocirrhosis have been described 4:

  • hepatic capsular retraction in response to chemotherapeutic agents, with nodular regenerative hyperplasia and absence of bridging fibrosis or cirrhosis on histopathology
  • extensive fibrosis representing a profound desmoplastic response to the infiltrating tumor, occurring prior to chemotherapy

Radiographic features

Radiological manifestations on CT, ultrasound, and MR may be identical to liver cirrhosis, and consist of:

Hepatobiliary pathology
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Article information

rID: 28123
Section: Gamuts
Synonyms or Alternate Spellings:
  • Pseudo cirrhosis

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