Citation, DOI & article data
Citation:
Weerakkody, Y., El-Feky, M. Pseudohypoparathyroidism. Reference article, Radiopaedia.org. (accessed on 27 Jun 2022) https://doi.org/10.53347/rID-10836
Pseudohypoparathyroidism (PHP) is a condition where there is end-organ resistance to parathyroid hormone (PTH).
Pseudohypoparathyroidism has an estimated prevalence of 1.1 per 100,000 people 6.
- Hypocalcemia and tetany
- Short stature
- Developmental delay
Subtypes
There are several recognized subtypes which include:
-
type I: abnormal cAMP response to PTH stimulation
-
type II: normal cAMP response to PTH stimulation
Markers
- parathyroid hormone level: high
- serum phosphate level: high
- serum calcium level: low
Musculoskeletal manifestations
CNS / head and neck manifestations
- 1. Zung A, Herzenberg JE, Chalew SA. Radiological case of the month. Ectopic ossification and calcification in pseudohypoparathyroidism and pseudopseudohypoparathyroidism. Arch Pediatr Adolesc Med. 1996;150 (6): 643-4. Arch Pediatr Adolesc Med (link) - Pubmed citation
- 2. Burnstein MI, Kottamasu SR, Pettifor JM et-al. Metabolic bone disease in pseudohypoparathyroidism: radiologic features. Radiology. 1985;155 (2): 351-6. Radiology (abstract) - Pubmed citation
- 3. Balkissoon AR, Hayes CW. Case 14: intramedullary osteosclerosis. Radiology. 1999;212 (3): 708-10. Radiology (full text) - Pubmed citation
- 4. Boutboul S, Bourcier T, Heligon JP et-al. Familial pseudotumoral sclerochoroidal calcification associated with chondrocalcinosis. Br J Ophthalmol. 2004;88 (8): 1094-5. doi:10.1136/bjo.2003.039925 - Free text at pubmed - Pubmed citation
- 5. Shields JA, Shields CL. CME review: sclerochoroidal calcification: the 2001 Harold Gifford Lecture. Retina (Philadelphia, Pa.). 2002;22 (3): 251-61. Pubmed citation
- 6. Line Underbjerg, Tanja Sikjaer, Leif Mosekilde et-al. Pseudohypoparathyroidism – epidemiology, mortality and risk of complications. (2016) Clinical Endocrinology. 84 (6): 904. doi:10.1111/cen.12948 - Pubmed
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