Pseudolipoma of the Glisson capsule
Citation, DOI, disclosures and article data
At the time the article was created Matt A. Morgan had no recorded disclosures.
View Matt A. Morgan's current disclosuresAt the time the article was last revised Henry Knipe had the following disclosures:
- Micro-X Ltd, Shareholder (past)
These were assessed during peer review and were determined to not be relevant to the changes that were made.
View Henry Knipe's current disclosures- Pseudolipomas of Glisson's capsule
- Glisson capsule lipoma
- Hepatic pseudolipoma
- Hepatic pseudolipomas
- Pseudolipomas of the Glisson capsule (PGC)
Pseudolipomas of the Glisson capsule are rare anomalies where a piece of degenerated fat is located within the liver capsule.
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Pathology
These pseudolipomas are more frequently acquired than congenital and are mostly thought to be a detached epiploic appendage that become lodged in the hepatic subscapular space (between the inner fibrous Glisson layer and the outer serosal layer) 3,4. They have been reported to migrate 4.
Radiographic features
CT
well-circumscribed fat attenuation (-20 to -70 HU) nodule at the liver surface
it can sometimes have soft tissue attenuation and can have a small peripheral calcification 3
MRI
well-circumscribed nodule at the liver surface that follows fat signal intensity on all sequences and suppresses with fat saturation
Differential diagnosis
They might be mistaken by peripheral intra-hepatic fat-containing lesions and, therefore, the differential diagnosis would include:
metastases from lipid-containing tumors, e.g. liposarcoma 3
Other differentials considerations include:
References
- 1. Prasad S, Wang H, Rosas H et al. Fat-Containing Lesions of the Liver: Radiologic-Pathologic Correlation. Radiographics. 2005;25(2):321-31. doi:10.1148/rg.252045083 - Pubmed
- 2. Podgorska J, Anysz-Grodzicka A, Cieszanowski A. State-Of-The-Art MR Imaging of Fat-Containing Focal Lesions of the Liver. Curr Med Imaging Rev. 2019;15(5):435-42. doi:10.2174/1573405614666171218154838 - Pubmed
- 3. Lee J, Kim S, Kwack S et al. Hepatic Capsular and Subcapsular Pathologic Conditions: Demonstration with CT and MR Imaging. Radiographics. 2008;28(5):1307-23. doi:10.1148/rg.285075089 - Pubmed
- 4. Peltier J, Demuynck F, Fichten A et al. Non-Traumatic Pseudocyst of Glisson Capsule Complicating a Ventriculoperitoneal Shunt. Neurochirurgie. 2011;57(1):31-3. doi:10.1016/j.neuchi.2009.11.004 - Pubmed
- 5. Kiolbasa M, Thimmappa N, Stensby J. Migrating Pseudolipoma of Glisson's Capsule. Clin Imaging. 2021;69:1-3. doi:10.1016/j.clinimag.2020.06.033
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