Pulmonary metastases

Pulmonary metastases are common and the result of metastatic spread from a variety of primary tumors via blood or lymphatics.

This article describes haematogenous pulmonary metastases with lymphangitis carcinomatosis discussed separately.

The epidemiology will match that of the underlying malignancy (see below), but as malignancies increase in incidence with increasing age, so does the presence of pulmonary metastases.

Pulmonary metastases are usually asymptomatic, with constitutional symptoms relating to disseminated metastatic disease and those attributable to the primary tumor dominating 5. Hemoptysis and pneumothorax are sometimes the presenting symptoms.

Tumor cells reach the lungs via the pulmonary circulation, where they lodge in small distal vessels.

The most common primaries to result in pulmonary metastases in adults include 1,3:

In the pediatric population, the most common primaries for pulmonary metastases are:

Alternatively, primaries which most frequently metastasize to lungs (although are much less common) include 1,3:

Primaries that metastasize as endobronchial deposits can include:

Pulmonary metastases typically appear as peripheral, rounded nodules of variable size, scattered throughout both lungs 1. Atypical features include consolidation, cavitation, calcification, hemorrhage, and secondary pneumothorax.

Plain films are insensitive, although frequently able to make the diagnosis, as often pulmonary metastases are large and numerous.

CT is excellent at visualizing pulmonary nodules. Typically, metastases appear of soft tissue attenuation, well circumscribed, rounded lesions, more often in the periphery of the lung. They are usually of variable size, a feature which is of some use in distinguishing them from a granuloma 3.

A prominent pulmonary vessel has frequently been noted heading into a metastasis. This has been termed the feeding vessel sign 4. It is unclear whether this is a true finding or the result of older scanners with thicker slices resulting in volume averaging 4. However, a number of atypical features are commonly encountered.

Some tumors have a predilection for innumerable small metastases (miliary pattern):

Conversely, a pulmonary metastasis may be single. This is most frequently seen in colorectal carcinoma. Other primaries which often present with solitary metastases include 3:

Adenocarcinoma metastases, rather than displace or destroy adjacent lung parenchyma, may grow in a lepidic fashion (spread along alveolar walls) resulting in pneumonia-like consolidation. Air bronchograms may also be visible 1.

Cavitation is present in ~4% of cases 1. The most common primary is squamous cell carcinoma, most often from the head and neck or from the lung. Other primaries include adenocarcinomas, and sarcomas 1,3.

Calcification, although uncommon and more frequently a feature of benign etiology (e.g. granuloma or hamartoma) is also seen with metastases, particularly those from papillary thyroid carcinoma and adenocarcinomas. Treated metastases, osteosarcomas and chondrosarcomas may also contain calcified densities 1.

A halo of ground-glass opacity representing hemorrhage can be seen, particularly surrounding hemorrhagic pulmonary metastases, such as choriocarcinoma and angiosarcoma 1.

Although not used routinely, MRI may be as sensitive in the detection of pulmonary metastases as CT 2,4.

In general presence of pulmonary metastases is an ominous finding, indicating poor prognosis. The specific prognosis will, however, depend on the primary tumor.

Tumors with prominent necrosis located near a pleural surface may result in a pneumothorax. Osteosarcoma is classically described as the pulmonary metastasis that results in pneumothorax. Another cause of pneumothoraces includes cystic or cavitary pulmonary metastases.

The differential depends on the number of nodules/masses and their imaging characteristics.


Article information

rID: 8854
System: Chest, Oncology
Section: Gamuts
Synonyms or Alternate Spellings:
  • pulmonary mets
  • lung mets
  • Lung metastases
  • Pulmonary metastasis
  • Lung metastasis
  • Metastases to the lung
  • Metastases to lung

ADVERTISEMENT: Supporters see fewer/no ads

Cases and figures

  • Case 1: canon-ball metastases from breast cancer
    Drag here to reorder.
  • Case 2: from colorectal carcinoma
    Drag here to reorder.
  • Case 3: thyroid primary
    Drag here to reorder.
  • Case 4: miliary metastases papillary ca of the thyroid
    Drag here to reorder.
  • Lung Metastasis
    Case 5: from renal cell cancer
    Drag here to reorder.
  • Multiple well sof...
    Case 6: from testicular cancer
    Drag here to reorder.
  • Case 7: from prostate cancer
    Drag here to reorder.
  • Case 8
    Drag here to reorder.
  • Case 9: from osteosarcoma
    Drag here to reorder.
  • Case 10: cavitary metastases
    Drag here to reorder.
  • Case 11: from colorectal cancer
    Drag here to reorder.
  • Case 12: from testicular cancer
    Drag here to reorder.
  • Case 13: from RCC
    Drag here to reorder.
  • Case 14: from salivary gland carcinoma
    Drag here to reorder.
  • Case 15: from osteosarcoma
    Drag here to reorder.
  • Case 16: from carotid body tumor
    Drag here to reorder.
  • Case 17: from lung primary
    Drag here to reorder.
  • Case 18: leiomyosarcoma primary
    Drag here to reorder.
  • Updating… Please wait.

     Unable to process the form. Check for errors and try again.

     Thank you for updating your details.