Pulmonary necrotizing granuloma
Pulmonary necrotizing granuloma refers to rather blanket term covering a group of entities which can result in granuloma formation with associated necrosis.
On a pathologic specimen a necrotizing granuloma comprises of aggregates of macrophages transformed into epithelium-like cells surrounded by a collar of mononuclear leukocytes (principally lymphocytes and occasional plasma cells) with a surrounding area of necrosis.
They can result from both infectious and non infectious causes.
According to a recent study, most of these were caused by unexplained etiology 1. Of the known etiologies, infectious causes tend to be more commoner.
The pathological spectrum includes
- non infectious
- 1. Mukhopadhyay S, Wilcox BE, Myers JL et-al. Pulmonary necrotizing granulomas of unknown cause: clinical and pathologic analysis of 131 patients with completely resected nodules. Chest. 2013;144 (3): 813-24. doi:10.1378/chest.12-2113 - Pubmed citation
- 2. Thiessen R, Seely JM, Matzinger FR et-al. Necrotizing granuloma of the lung: imaging characteristics and imaging-guided diagnosis. AJR Am J Roentgenol. 2007;189 (6): 1397-401. doi:10.2214/AJR.07.2389 - Pubmed citation