Pulmonary ossification

Pulmonary ossification (PO) is a rare finding and is characterised by the presence of mature bone in alveolar or interstitial spaces, either localised or disseminated throughout the lung parenchyma.

It can be idiopathic (idiopathic pulmonary ossification) or secondary to chronic lung, cardiac or systemic disorders 1.

Pathology

It is thought to be a result of multiple interacting factors. Tissue injury is considered the most important provoking factor which, in an alkaline environment, initiates calcium salt precipitation, enables alkaline phosphatase activity, and activates profibrogenic cytokines. Alveolar haemorrhage is responsible for interstitial metallic deposition that attracts calcium salts and multinucleated giant cells. 

Morphological subtypes
Associations

See also

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Article information

rID: 25513
System: Chest
Section: Gamuts
Tag: cases
Synonyms or Alternate Spellings:
  • Pulmonary ossification (PO)
  • Lung ossificiation
  • Diffuse pulmonary ossfication
  • Diffuse lung ossificiation
  • Diffuse pulmonary ossfication (DPO)

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Cases and figures

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    Case 1: dendriform
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