Pulmonary scedoporium infection
Pulmonary scedoporium infection is a form of extremely rare pulmonary fungal infection. Scedosporium can present as focal localized to widespread systemic disease.
It typically occurs in immunucompromised patients. Both acute and chronic forms have been described.
This occurs due to infection with several species such as
- Scedoporium prolificans
- Scedoporium angiospermum
It may give a clinical presentation similar to that of pulmonary aspergillosis.
There are currently very little publications on the imaging features at the time of initial writing. If youre are an expert on this we would love your help :).
Cavitating lung lesions (mycetomas) have been reported 8.
Treatment and prognosis
Scedosporium infections in transplant recipients have been reported to have high rates of dissemination and a poor overall outcome. It is usually resistant to traditional antifungal agents, and may respond to prompt management with triazoles (variconazole).
- 1. Abgrall S, Pizzocolo C, Bouges-Michel C et-al. Scedosporium apiospermum lung infection with fatal subsequent postoperative outcome in an immunocompetent host. Clin. Infect. Dis. 2007;45 (4): 524-5. doi:10.1086/520009 - Pubmed citation
- 2. Koga T, Kitajima T, Tanaka R et-al. Chronic pulmonary scedosporiosis simulating aspergillosis. Respirology. 2005;10 (5): 682-4. doi:10.1111/j.1440-1843.2005.00769.x - Pubmed citation
- 3. Al Refaï M. European Journal of Cardio-Thoracic Surgery.21 (5): . doi:10.1016/S1010-7940(02)00068-4
- 4. Husain S, Muñoz P, Forrest G et-al. Infections due to Scedosporium apiospermum and Scedosporium prolificans in transplant recipients: clinical characteristics and impact of antifungal agent therapy on outcome. Clin. Infect. Dis. 2005;40 (1): 89-99. doi:10.1086/426445 - Pubmed citation
- 5. Sarva ST, Manjunath SK, Baldwin HS et-al. Lung scedosporiosis in human immunodeficiency virus/acquired immunodeficiency syndrome. Am. J. Med. Sci. 2010;339 (3): 300-3. doi:10.1097/MAJ.0b013e3181cec4be - Pubmed citation
- 6. Karoll J. Cortez, Emmanuel Roilides, Flavio Quiroz-Telles, Joseph Meletiadis, Charalampos Antachopoulos, Tena Knudsen, Wendy Buchanan, Jeffrey Milanovich, Deanna A. Sutton, Annette Fothergill, Michael G. Rinaldi, Yvonne R. Shea, Theoklis Zaoutis, Shyam Kottilil, Thomas J. Walsh. Infections Caused by Scedosporium spp. (2008) Clinical Microbiology Reviews. 21 (1): 157. doi:10.1128/CMR.00039-07 - Pubmed
- 7. Masukane S, Kitahara Y, Okumoto J, Sasaki K, Nakano K. The Effective Treatment of Lung Infection Due to Scedosporium prolificans with Voriconazole and Surgery. (2017) Internal medicine (Tokyo, Japan). 56 (8): 973-977. doi:10.2169/internalmedicine.56.7447 - Pubmed
- 8. Ma KC, Pino A, Narula N, Turetz ML. Scedosporium apiospermum Mycetoma in an Immunocompetent Patient without Prior Lung Disease. (2017) Annals of the American Thoracic Society. 14 (1): 145-147. doi:10.1513/AnnalsATS.201609-697LE - Pubmed