Pulmonary talc granulomatosis

Pulmonary talc granulomatosis is one of forms of talc induced pulmonary disease. It is mainly caused by injection of tablets intended for oral consumption.

Pathology

It is characterised by the development of foreign body granuloma secondary to talc exposure.

The exact pathophysiological mechanism for this is not well known. Talc embolisation is thought to result in an initial inflammatory arteritis, associated with a rapid influx of neutrophils around talc particles. Migration of particles to the surrounding perivascular and pulmonary interstitial tissue with subsequent foreign body granuloma development.

Radiographic features

Plain film - chest radiograph

There can be widespread small  (2-3 mm) well-defined nodules, there may be mid zone predilection. With disease progression, the nodules coalesce and massive fibrosis can occur. 

HRCT

May show a diffuse nodules, a ground-glass pattern with emphysema. 

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Article Information

rID: 25698
System: Chest
Tag: cases
Synonyms or Alternate Spellings:
  • Talc granulomatosis of lung
  • Talc granulomatosis of lungs
  • Talc granulomatosis of the lung
  • Talc granulomatosis of the lungs
  • Talc induced pulmonary granulomatosis

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