Pulmonary valve regurgitation

Pulmonary valve regurgitation, also known as pulmonary valve insufficiency or pulmonary valve incompetence, is a valvulopathy that describes leaking of the pulmonary valve diastole that causes blood to flow in the reverse direction from the pulmonary trunk and into the right ventricle.

Prevalence of pulmonary regurgitation is thought to have two demographical peaks, firstly in young patients with repaired congenital pulmonary stenosis or right ventricular outflow tract obstruction repairs, or secondly in patients with pulmonary arterial hypertension 1. As such, given the multitude of causes, the exact prevalence is difficult to determine.

Clinical features can vary dependent of the severely of the pulmonary regurgitation, and often only manifest when pulmonary regurgitation is severe 1,2. When symptomatic, it eventually leads to right-predominant clinical features of heart failure 1,2. Depending on the etiology, patients may have clinical features of pulmonary hypertension 1,2.

Clinical examination classically reveals a right ventricular heave on praecordial palpation, and an early diastolic murmur that is heard on praecordial auscultation known as the Graham Steell murmur 1-3. Occasionally the murmur heard may be holodiastolic, reflecting increased disease severity 1,2.

The characteristic hemodynamic feature of severe pulmonary regurgitation, similarly to the effect of aortic regurgitation on the left side of the heart, is enlargement of the right ventricle in response to right ventricular overload and an effort to maintain cardiac output 1,2. This results in right ventricular dysfunction, explaining the clinical features of this valvulopathy, and functional tricuspid regurgitation 1,2. At this point, there is also a decrease in the cardiac output 1,2.

Etiologies of pulmonary regurgitation can be considered primary, where there is valvular pathology, or secondary ('functional'), where there is dilation of the annulus as a result of pulmonary arterial hypertension or pulmonary artery dilation 1,2. Overall, secondary pulmonary regurgitation is more common than primary pulmonary regurgitation 1,2.

Primary causes include 1,2,4,5:

​Disorders leading to secondary (functional) pulmonary regurgitation include 1,2,4,5:

Signs of pulmonary regurgitation on chest radiograph are often subtle, but include 1:

Echocardiography is useful for evaluating the cause of pulmonary regurgitation, for assessing the regurgitant volume, and for assessing the right-sided cardiac chambers 4. The echocardiographic detection of minor or trivial pulmonary regurgitation is common, and present in up to 78% of people 4.

For pathological pulmonary regurgitation, various parameters are used in order to determine severity, such as 4:

  • mild
    • pulmonary valve normal
    • right ventricular size normal 
    • central jet thin
    • jet density soft
    • jet deceleration slow
    • pulmonary systolic flow compared to systemic flow slightly increased
  • moderate
    • pulmonary valve may be normal or abnormal
    • right ventricular size may be normal or abnormal 
    • central jet intermediate
    • jet density dense
    • jet deceleration variable
    • pulmonary systolic flow compared to systemic flow intermediate
  • severe
    • pulmonary valve abnormal
    • right ventricular size dilated 
    • central jet usually large with a wide origin
    • jet density dense
    • jet deceleration steep
    • pulmonary systolic flow compared to systemic flow greatly increased

Additionally, the shape of the pulmonary annulus can also be measured with echocardiography, although this is often technically challenging 4

Cross-sectional imaging demonstrate the same radiographic features appreciated on plain film and echocardiography, but in greater detail 5,6. In particular, cardiac MRI may be particularly useful for accurate measurements to assess the severity of the valvulopathy and for assessing areas of the heart that are technically challenging to review with echocardiography (e.g. the pulmonary annulus, the right ventricular outflow tract) 5,6.

The decision to treat pulmonary regurgitation is based on its severity 1. Management involves pharmacotherapy measures (especially diuretics and management of underlying pulmonary arterial hypertension) and consideration of surgery in primary disease 1. Details of this management is beyond the scope of this article.

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Article information

rID: 57549
System: Cardiac
Synonyms or Alternate Spellings:
  • Pulmonary regurgitation
  • Pulmonary valve insufficiency
  • Pulmonary insufficiency
  • Pulmonary valve incompetence
  • Pulmonary incompetence
  • Pulmonic valve regurgitation
  • Pulmonic regurgitation
  • Pulmonic valve insufficiency
  • Pulmonic insufficiency
  • Pulmonic valve incompetence
  • Pulmonic incompetence

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