Pulvinar sign (CNS)
Citation, DOI, disclosures and article data
At the time the article was created Maxime St-Amant had no recorded disclosures.
View Maxime St-Amant's current disclosuresAt the time the article was last revised Rohit Sharma had no financial relationships to ineligible companies to disclose.
View Rohit Sharma's current disclosures- Pulvinar sign (Creutzfeldt-Jakob disease)
- Pulvinar sign
The pulvinar sign refers to bilateral FLAIR hyperintensities involving the pulvinar thalamic nuclei 1,2. It is classically described in variant Creutzfeldt-Jakob disease and is part of the World Health Organization diagnostic criteria for this condition 2.
The pulvinar sign may also be described in other neurological conditions:
sporadic Creutzfeldt-Jakob disease 3
Fabry disease: the hyperintense signal is seen on T1 rather than T2 4
See also
hockey stick sign: additional involvement of the medial thalamus
References
- 1. Molloy S, O'Laoide R, Brett F, Farrell M. The “Pulvinar” Sign in Variant Creutzfeldt-Jakob Disease. AJR Am J Roentgenol. 2000;175(2):555-6. doi:10.2214/ajr.175.2.1750555
- 2. Collie D, Summers D, Sellar R et al. Diagnosing Variant Creutzfeldt-Jakob Disease with the Pulvinar Sign: MR Imaging Findings in 86 Neuropathologically Confirmed Cases. AJNR Am J Neuroradiol. 2003;24(8):1560-9. PMC7973975 - Pubmed
- 3. Petzold G, Westner I, Bohner G, Einhäupl K, Kretzschmar H, Valdueza J. False-Positive Pulvinar Sign on MRI in Sporadic Creutzfeldt–Jakob Disease. Neurology. 2004;62(7):1235-6. doi:10.1212/01.wnl.0000123265.91365.af
- 4. Cocozza S, Russo C, Pisani A et al. Redefining the Pulvinar Sign in Fabry Disease. AJNR Am J Neuroradiol. 2017;38(12):2264-9. doi:10.3174/ajnr.a5420 - Pubmed
- 5. Dabadghao V, Ostwal P, Sharma S, Garg S. Pulvinar Sign in Acute Disseminated Encephalomyelitis. Ann Indian Acad Neurol. 2014;17(2):214-6. doi:10.4103/0972-2327.132640 - Pubmed
- 6. Ohe Y, Hayashi T, Deguchi I et al. MRI Abnormality of the Pulvinar in Patients with Status Epilepticus. J Neuroradiol. 2014;41(4):220-6. doi:10.1016/j.neurad.2013.09.003 - Pubmed
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Related articles: Neurodegenerative diseases
Neurodegenerative diseases are legion and their classification just as protean. A useful approach is to divide them according to underlying pathological process, although even using this schema, there is much overlap and thus resulting confusion.
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neurodegenerative MRI brain (an approach)
- measurements and ratios
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- signs
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- scoring systems
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tauopathies
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Alzheimer disease
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prion diseases (not always included as neurodegenerative)
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