Pure ground glass nodules
Last revised by Yuranga Weerakkody on 28 Jan 2024
Citation, DOI, disclosures and article data
Citation:
Weerakkody Y, Bell D, Rock P, et al. Pure ground glass nodules. Reference article, Radiopaedia.org (Accessed on 23 Apr 2024) https://doi.org/10.53347/rID-28314
Permalink:
rID:
28314
Article created:
20 Mar 2014,
Yuranga Weerakkody ◉
Disclosures:
At the time the article was created Yuranga Weerakkody had no recorded disclosures.
View Yuranga Weerakkody's current disclosures
Last revised:
28 Jan 2024,
Yuranga Weerakkody ◉
Disclosures:
At the time the article was last revised Yuranga Weerakkody had no financial relationships to ineligible companies to disclose.
View Yuranga Weerakkody's current disclosures
Revisions:
13 times, by
4 contributors -
see full revision history and disclosures
Sections:
Synonyms:
- Pure ground glass lung nodules
- Pure ground glass pulmonary nodules
- Pure ground glass nodular opacities
- Pure ground glass nodular opacity
- Pure ground glass lung nodule
- Pure ground glass pulmonary nodule
- Nonsolid nodule
- Pure ground glass nodule pGGN
- Pulmonary subsolid nodules
- Pulmonary subsolid nodule
Pure ground glass lung nodules (pGGN's) are a subtype of ground glass lung nodules where there is no associated solid component.
On this page:
Pathology
Aetiology
Apart from inflammatory foci they have been shown to represent various pathologies such as 1,3
- adenocarcinoma in situ of lung
- minimally-invasive adenocarcinoma of lung
- invasive adenocarcinoma of lung
- atypical adenomatous hyperplasia of lung
- focal interstitial fibrosis
- isolated focal area of infection / pneumonitis
Treatment and prognosis
According to one study, conducted in nodules measuring between 3-20 mm over a two-year period without a history of malignancy, 90% did not grow on follow-up 2.
See also
References
- 1. Lim HJ, Ahn S, Lee KS et-al. Persistent pure ground-glass opacity lung nodules ≥ 10 mm in diameter at CT scan: histopathologic comparisons and prognostic implications. Chest. 2013;144 (4): 1291-9. doi:10.1378/chest.12-2987 - Pubmed citation
- 2. Chang B, Hwang JH, Choi YH et-al. Natural history of pure ground-glass opacity lung nodules detected by low-dose CT scan. Chest. 2013;143 (1): 172-8. doi:10.1378/chest.11-2501 - Pubmed citation
- 3. Kim TJ, Goo JM, Lee KW et-al. Clinical, pathological and thin-section CT features of persistent multiple ground-glass opacity nodules: comparison with solitary ground-glass opacity nodule. Lung Cancer. 2009;64 (2): 171-8. doi:10.1016/j.lungcan.2008.08.002 - Pubmed citation
- 4. M. Infante, R. F. Lutman, S. Imparato, M. Di Rocco, G. L. Ceresoli, V. Torri, E. Morenghi, F. Minuti, S. Cavuto, E. Bottoni, F. Inzirillo, U. Cariboni, V. Errico, M. A. Incarbone, G. Ferraroli, G. Brambilla, M. Alloisio, G. Ravasi. Differential diagnosis and management of focal ground-glass opacities. (2009) European Respiratory Journal. 33 (4): 821. doi:10.1183/09031936.00047908 - Pubmed
- 5. Milanese G, Sverzellati N, Pastorino U, Silva M. Adenocarcinoma in Pure Ground Glass Nodules: Histological Evidence of Invasion and Open Debate on Optimal Management. J Thorac Dis. 2017;9(9):2862-7. doi:10.21037/jtd.2017.08.120
- 6. Cohen J & Ferretti G. Pure Ground-Glass Nodules: Are They Really Indolent? J Thorac Dis. 2017;9(9):2839-42. doi:10.21037/jtd.2017.08.89 - Pubmed
- 7. Lee H, Choi Y, Lee K et al. Pure Ground-Glass Opacity Neoplastic Lung Nodules: Histopathology, Imaging, and Management. AJR Am J Roentgenol. 2014;202(3):W224-33. doi:10.2214/AJR.13.11819 - Pubmed
- 8. Kim H, Park C, Koh J, Lee S, Goo J. Pulmonary Subsolid Nodules: What Radiologists Need to Know About the Imaging Features and Management Strategy. Diagn Interv Radiol. 2014;20(1):47-57. doi:10.5152/dir.2013.13223 - Pubmed
- 9. Lee J, Hong J, Kim H. Guidelines for the Investigation and Management of Ground Glass Nodules. J Chest Surg. 2021;54(5):333-7. doi:10.5090/jcs.21.021 - Pubmed
- 10. Kim Y. Management of Ground-Glass Nodules: When and How to Operate? Cancers (Basel). 2022;14(3):715. doi:10.3390/cancers14030715 - Pubmed