Radiation-induced breast cancer
Citation, DOI & article data
Besides breast cancer, sarcomas (breast angiosarcoma or osteosarcomas arising from the irradiated bones), lung cancer, malignant pleural mesothelioma, and esophageal cancers are also potential induced malignancies in those patients receiving radiotherapy to the chest 2.
The latency period since the completion of radiotherapy and the development of breast cancer has been reported in between 8 to 20 years 2.
Risk of breast cancer is 75 times greater in those women that received radiation therapy for Hodgkin's lymphoma 1,2.
The most common histological subtypes of radiation-induced breast cancers are 3:
Besides location within the irradiated field 2, there are no other specific imaging features of the tumors themselves that differ radiation-induced from the sporadic breast cancers. Please refer to the parental article on breast cancer for further details.
Treatment and complications
It is well-established that women that received thoracic radiotherapy before the age of 30 should be included earlier in the routine breast screening 1,2.
- 1. Benoît Mesurolle, Salah Dine Qanadli, Myriam Merad, François Mignon, Pierre Baldeyrou, Anne Tardivon, Pascal Lacombe, Daniel Vanel. Unusual Radiologic Findings in the Thorax after Radiation Therapy1. (2000) RadioGraphics. 20 (1): 67-81. doi:10.1148/radiographics.20.1.g00ja1167 - Pubmed
- 2. Marcelo F. Benveniste, Daniel Gomez, Brett W. Carter, Sonia L. Betancourt Cuellar, Girish S. Shroff, Ana Paula A. Benveniste, Erika G. Odisio, Edith M. Marom. Recognizing Radiation Therapy–related Complications in the Chest. (2019) RadioGraphics. 39 (2): 344-366. doi:10.1148/rg.2019180061 - Pubmed
- 3. Bhatia, Smita, Robison, Leslie L., Oberlin, Odile, Greenberg, Mark, Bunin, Greta, Fossati-Bellani, Franca, Meadows, Anna T.. Breast Cancer and Other Second Neoplasms after Childhood Hodgkin's Disease. (2009) The New England journal of medicine. 334 (12): 745-51. doi:10.1056/NEJM199603213341201 - Pubmed