Radiation-induced cerebral vasculopathy

Radiation-induced cerebral vasculopathy encompasses a complex and broad range of effects on the intra- and extracranial vessels resulting from injury from radiation exposure.

Clinical symptoms are broad and depend on the underlying vasculopathy. Radiation-induced telangiectasia and microbleeds may be asymptomatic. However, patients may present with focal neurological deficits resulting from both haemorrhagic and ischaemic stroke, lacunar lesions, vascular occlusive disease including moyamoya syndrome, vascular malformations, and radiation-induced necrosis.

Biopsy and pathological analysis of radiation-induced telangiectasias have demonstrated deposition of perivascular haemosiderin and haemorrhage adjacent to capillary-sized telangiectasia (pre-existing dilated channels rather than proliferating vascular neoplasm) 3.

Arterial stenosis and occlusion involving both large and small-sized intracranial and extracranial vessels.

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rID: 39012
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Cases and figures

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    Case 1: microhaemorrhages
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    Case 2: radionecrosis
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