Radiation-induced MRI signal changes in bone

Radiation-induced MRI signal changes in bone are the earliest detectable changes in bone. They increase with increase in the radiation dose.


  • 1st week: decreased marrow cellularity with oedema and haemorrhage
  • 2nd week: increased marrow cellularity due to influx from unirradiated areas
  • 1-3 months: marrow sinusoids and cellularity is decreased
  • after 6 months: regenration of hematopoetic tissue and sinusoids

Radiographic features


Little changes in signal intensity during first 3 weeks of radiation therapy on spin echo sequences. STIR shows increased signal intensity during this period .

After 3 weeks heterogenous mottled appearance of marrow is seen.

During 3-6 weeks marrow cellularity is replaced by central fat predominantly surrounding the basivertebral veins.

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Article information

rID: 26025
Section: Gamuts
Tag: cases, refs
Synonyms or Alternate Spellings:
  • Radiation related bone MRI changes
  • Radiation induced MRI signal changes in bone

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Cases and figures

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    Case 1: chronic radiation induced fatty marrow replacement
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