The Rai staging system is one of the two staging systems currently adopted in assessment of chronic lymphocytic leukaemia (CLL).
It comprises of stages 0 to IV and classifies chronic lymphocytic leukaemia into low, intermediate and high-risk categories, which correspond with stages 0, I and II, and III and IV, respectively:
-
Rai stage 0
- low risk
- lymphocytosis: a high lymphocyte count defined as more than 15,000 lymphocytes per cubic millimetre (> 15,000/mm3)
-
Rai stage I
- intermediate risk
- lymphocytosis and lymphadenopathy
-
Rai stage II
- patients are also intermediate risk
- lymphocytosis plus an enlarged liver (hepatomegaly) or enlarged spleen (splenomegaly), with or without lymphadenopathy
-
Rai stage III
- patients are high-risk
- lymphocytosis plus anaemia with or without lymphadenopathy, hepatomegaly, or splenomegaly
-
Rai stage IV
- high-risk
- lymphocytosis + thrombocytopenia (< 100-103 /dL)
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