Ranke complex (tuberculosis)
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At the time the article was created Frank Gaillard had no recorded disclosures.View Frank Gaillard's current disclosures
At the time the article was last revised Daniel J Bell had no recorded disclosures.View Daniel J Bell's current disclosures
Ranke complex is seen in 'healed' primary pulmonary tuberculosis and is a later manifestation of the Ghon complex. It consists of two components:
- a Ghon lesion that has undergone calcification
- an ipsilateral calcified mediastinal node
It is important to note that a Ranke complex is not specific (see below).
History and etymology
Karl Ernest Ranke (1870-1926) was a German physician who developed the (now outdated) hypothesis on the pathology of pulmonary tuberculosis, which became known as "Ranke's stages of tuberculosis" 2.
It should be noted that the imaging findings are completely non-specific. Sequelae of other granulomatous infections, such as healed thoracic histoplasmosis, can have identical imaging findings 3.
More rarely, a calcified or ossified lung metastasis 4 with ipsilateral hilar lymphadenopathy (e.g. from metastatic mucinous adenocarcinoma, osteosarcoma, or epithelial ovarian neoplasms 5) could give a similar imaging appearance.
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- 5. Santiago Martínez-Jiménez, Melissa L. Rosado-de-Christenson, Christopher M. Walker, Jeffery R. Kunin, Sonia L. Betancourt, Brenda L. Shoup, Paul P. Pettavel. Imaging Features of Thoracic Metastases from Gynecologic Neoplasms. (2014) RadioGraphics. 34 (6): 1742-54. doi:10.1148/rg.346140052 - Pubmed