Rapidly progressive interstitial lung disease
Rapidly progressive interstitial lung disease (RP-ILD) is a temporal descriptive term for forms interstitial lung disease which cam progress rapidly through time (a quantitative census on the temporal time frame however has not been published at the the time of the study (i.e. there is some subjectivity). There is also no clear morphological descriptor for this pattern.
Situations which this has been described include
- anti-MDA5 antibody-positive amyopathic dermatomyositis associated interstitial lung disease 1
- interstitial lung disease associated with systemic sclerosis (SSc-ILD) 2.
- acute interstitial pneumonitis (AIP) 3
- forms of acute respiratory distress syndrome (ARDS): debatable as to if this should be in this group as often it is the acute pneumonic process that progresses rather than the fibrotic component.
- 1. Chino H, Sekine A, Baba T, Kitamura H, Iwasawa T, Okudela K, Takemura T, Itoh H, Sato S, Suzuki Y, Ogura T. Interstitial Lung Disease with Anti-melanoma Differentiation-associated Protein 5 Antibody: Rapidly Progressive Perilobular Opacity. (2019) Internal medicine (Tokyo, Japan). doi:10.2169/internalmedicine.2328-18 - Pubmed
- 2. Cottin V, Brown KK. Interstitial lung disease associated with systemic sclerosis (SSc-ILD). (2019) Respiratory research. 20 (1): 13. doi:10.1186/s12931-019-0980-7 - Pubmed
- 3. Vourlekis JS, Brown KK, Cool CD, Young DA, Cherniack RM, King TE, Schwarz MI. Acute interstitial pneumonitis. Case series and review of the literature. (2000) Medicine. 79 (6): 369-78. doi:10.1097/00005792-200011000-00003 - Pubmed