Renal amyloidosis

Renal amyloidosis is a rare as an isolated entity but can be associated with systemic amyloidosis. Renal involvement from amyloidosis in pathological specimens is quite common. However, renal function compromise is rare. 

It usually manifests as nephrotic syndrome:

  • fever
  • abdominal pain
  • hypertension
  • proteinuria
  • oedema 
  • urinary symptoms when urinary tract is involved
Causes
  • primary amyloidosis
  • secondary amyloidosis - ageing, chronic infection, chronic inflammatory diseases, tumours, rheumatoid arthritis, Hodgkin's disease
Associations
Complications
Ultrasound

Non specific but may show

  • enlarged kidneys - characteristic finding in acute stages
  • increased echogenecity
  • prominent medullary pyramids
CT

May show

  • enlarged kidneys
  • heterogeous contrast enhancement
MRI

Again may show enlarged kidneys 

  • T2 - affected areas are hypointense
Angiography (DSA)

May show

  • irregular narrowing and tortousity of interlobar arteries
  • non visualisation of cortical arterial branches
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Article Information

rID: 25651
System: Urogenital
Sections: Gamuts, Pathology
Tag: cases
Synonyms or Alternate Spellings:
  • Amyloidosis of kidneys
  • Amylodosis of kidney
  • Amylodosis affecting the kidney
  • Amylodosis affecting the kidneys

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