Renal amyloidosis

Last revised by Dr Bruno Di Muzio on 01 Dec 2019

Renal amyloidosis is rare as an isolated entity but can be associated with systemic amyloidosis

Renal involvement is estimated to affect a large proportion of the patients with systemic amyloidosis, with about half of them dying of renal failure complications 8

It usually manifests as nephrotic syndrome:

Imaging findings tend to be non-specific and are not always present, but smaller and thinned cortex kidneys are seen in about 50% of patients with systemic amyloidosis 3,8. A note is made that, in acute stages, the kidneys may be enlarged. Rarely, amyloid deposition may create focal parenchymal mass lesions 3

  • increased echogenicity
  • prominent medullary pyramids
  • heterogeneous contrast enhancement
  • amorphous renal calcifications 3
  • T2: affected areas are hypointense
  • irregular narrowing and tortuosity of interlobar arteries
  • non-visualization of cortical arterial branches

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