Renal artery stenosis (RAS) refers to a narrowing of a renal artery. When the process occurs slowly, it leads to secondary hypertension. Acute renal artery stenosis does not lead to hypersecretion of renin.
When the stenosis occurs slowly, collateral vessels form and supply the kidney. The kidney wrongly senses the reduced flow as low blood pressure (via the juxtaglomerular apparatus) and releases a large amount of renin that converts angiotensinogen to angiotensin I. Angiotensin I is then converted to angiotensin II with the help of angiotensin converting enzyme (ACE) in the lungs. Angiotensin II is responsible for vasoconstriction and release of aldosterone which causes sodium and water retention, thus resulting in secondary hypertension.
Renal artery stenosis may be caused by several pathological processes:
- atherosclerosis (~75% of cases) involves the proximal renal artery
- fibromuscular dysplasia (~20%) involves the distal renal artery, younger population
- vasculitides (especially polyarteritis nodosa, Takayasu arteritis, radiation)
- neurofibromatosis type 1
- abdominal aortic coarctation
- aortic dissection
- segmental arterial mediolysis
Occurrence is not uncommon following a renal transplant.
Ultrasound, although most freely available, cheap and often used first line, is relatively operator-dependent and may prove time consuming.
- increased renal arterial resistive index (RI): a cut-off value of 0.7 may be a good approximation in clinical practice 9
- RI difference between kidneys > 0.05 - 0.07 9
- increased peak systolic velocity (PSV): some advocate 180cm/s 4
- increased renal-interlobar ratio (RIR): some advocate values greater than 5 3
- increased renal/aortic ratio (RAR) i.e. PSVrenal/PSVaorta: usually taken as >3.5, although some advocate >3 4
- turbulent flow in a post-stenotic area
- pulsus parvus et tardus waveform (slow-rising) due to stenosis
- intraparenchymal resitive indices > 0.8
- intraparenchymal acceleration time > 0.07 s
The three-dimensional reconstruction of the renal vascular tree provides a reliable method of visualizing the entire àvascular tree. Images are acquired with thin collimation and bolus tracking on the abdominal aorta. Sensitivity and specificity varying between 90 to 99% have been reported 7. Both the raw data and 3D reconstructions should be viewed. Additionally, supernumerary arteries may be identified.
Different imaging methods can be used:
- time of flight (TOF): whereby the high velocity of the blood jet at the level of stenosis appears as a loss of signal (black)
- phase contrast technique
- contrast enhanced MRA: gadolinium is used as a contrast agent
Three-dimensional reconstruction technique offers a sensitivity and specificity values around 90 to 100% 7. In some cases, renal impairment does not permit the use of contrast, in which case TOF imaging is beneficial.
ACE inhibitor scintigraphy
- the affected kidney with renovascular hypertension shows impaired function due to ACE inhibition; based on this principle scintigraphy has been very much useful for diagnosis of renal artery stenosis
- it is performed by IV administration of enalapril maleate after 15 minutes
- sequential images and scintigraphic curves are plotted for the renal cortex and pelvis; renal uptake is measured for every 1-2 min interval after administering the IV injection
- typical isotopes used are Tc-99m MAG3, Tc-99m DTPA or I-123 0-iodohippurate 6
- the scintigram will be interpreted as either low, intermediate or high probability
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- 2. Schwerk WB, Restrepo IK, Stellwaag M et-al. Renal artery stenosis: grading with image-directed Doppler US evaluation of renal resistive index. Radiology. 1994;190 (3): 785-90. Radiology (abstract) - Pubmed citation
- 3. Li JC, Wang L, Jiang YX et-al. Evaluation of renal artery stenosis with velocity parameters of Doppler sonography. J Ultrasound Med. 2006;25 (6): 735-42. J Ultrasound Med (full text) - Pubmed citation
- 4. House MK, Dowling RJ, King P et-al. Using Doppler sonography to reveal renal artery stenosis: an evaluation of optimal imaging parameters. AJR Am J Roentgenol. 1999;173 (3): 761-5. AJR Am J Roentgenol (abstract) - Pubmed citation
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- 7. Zucchelli PC. Hypertension and atherosclerotic renal artery stenosis: diagnostic approach. J. Am. Soc. Nephrol. 2002;13 Suppl 3 (suppl 3): S184-6. doi:10.1097/01.ASN.0000032547.12173.5E - Pubmed citation
- 8. Johnson PT, Halpern EJ, Kuszyk BS et-al. Renal artery stenosis: CT angiography-comparison of real-time volume-rendering and maximum intensity projection algorithms. Radiology. 1999;211 (2): 337-43. doi:10.1148/radiology.211.2.r99ap17337 - Pubmed citation
- 9. Granata A, Fiorini F, Andrulli S et-al. Doppler ultrasound and renal artery stenosis: An overview. J Ultrasound. 2009;12 (4): 133-43. doi:10.1016/j.jus.2009.09.006 - Free text at pubmed - Pubmed citation
Ultrasound - renal
- ultrasound (introduction)
- renal ultrasound
- renal stone
- focal lesion
- renal vascular
- renal transplant ultrasound