Retinoblastoma (staging)

Last revised by Henry Knipe on 20 Oct 2017

Retinoblastoma staging can be via a number of systems with various end-points and multiple systems are often used concurrently.


Reese Ellsworth classification

The Reese Ellsworth classification is assessed with fundoscopy and aims at predicting the chance of preserving the eye with external beam radiotherapy 3.

International Classification of Retinoblastoma

More relevant to radiology practice is the International Classification of Retinoblastoma, which predicts overall survival 1-4.

  • stage 0: patients treated conservatively
  • stage I: eye enucleated, completely resected histologically
  • stage II: eye enucleated, microscopic residual tumor
  • stage III: regional extension
    • A: overt orbital disease
    • B: preauricular or cervical lymph node extension
  • stage IV: metastatic disease
    • A: hematogenous metastasis without CNS involvement
      • single lesion
      • multiple lesions
    • B: CNS metastatic involvement
      1. prechiasmatic lesion
      2. CNS mass
      3. leptomeningeal disease

See also

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