Rhabdomyosarcoma staging is based on the Lawrence/Gehan staging system, which comprises of a combination of pretreatment staging and postoperative clinical grouping.
Stage
stage I: orbit, eyelid, head and neck (excluding parameningeal), genitourinary (non-bladder, non-prostate), N0 or 1, M0
stage II: bladder, prostate, extremity, trunk, parameningeal, other, <5 cm, N0, M0
stage III: bladder, prostate, extremity, trunk, parameningeal, other, >5 cm, N0 or 1, M0
stage IV: all others, any N, M1
IRS group postsurgical pathologic grouping
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group I
Ia: confined to organ of origin or muscle, completely resected (clear margins, negative regional nodes)
Ib: local extension beyond to organ or muscle of origin, completely resected (clear margins, negative regional nodes)
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group II
IIa: microscopic disease remaining at margins and negative regional nodes
IIb: positive regional nodes, negative margins
IIc: microscopic disease remaining at margins and positive regional nodes
group III: incomplete resection or biopsy findings indicating gross residual disease
group IV: distant metastases
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