Rhinoscleroma is a chronic granulomatous infection involving the upper respiratory tract due to Klebsiella rhinoscleromatis. It initially involves the nasal mucosae but it may progress to any other part of the upper respiratory tract.

Untreated rhinoscleroma slowly progresses over many years 1.

Patients most often present with nasal obstruction. Other nonspecific symptoms are often encountered such as epistaxis, rhinorrhea, dysphagia, stridor, and dysphonia.

Patients with rhinoscleroma are usually between 10 to 30 years old. Poor hygiene, prolonged close contact, and malnutrition are considered risk factors. It is endemic in Central America, Egypt, tropical Africa, India, and Indonesia 3.

Characteristic radiological feature of rhinoscleroma is the presence of nasal mass with the following criteria; 4, 5

  • bilateral or unilateral expansile nasal masses, lesions are usually homogeneous, hyperdense and non-enhancing
  • masses usually extend through the nasal nare anteriorly and into the adjacent paranasal sinuses
  • lesions line the sinus wall causing bone sclerosis, bone thinning (pressure atrophy) or it may absorb it with extra-sinus extension
  • no bone destruction which helps to differentiate it from malignant lesions
  • in longstanding cases, rhinoscleroma may extend to involve other parts of the upper respiratory tract, such as phayrnx with nodular infiltration of the orophayrnx, tonsillar bed, soft and hard palate. It may also show laryngotracheal involvement, the usual site of laryngeal involvement is the glottic–subglottic region showing concentric narrowing of the airway, thickening of the tracheal wall and nodular thickening of the tracheal mucosa 5

lesions demonstrate characteristic signal intensity 4,5:

  • T1: mild to marked high signal intensity secondary to increased protein content within Mikulicz cells and Russel bodies
  • T2:  hyperintense due to its high cellular component with hypointense foci of fibrosis
  • T1 C+ (Gd): inhomogeneous contrast enhancement secondary to areas of fibrosis.
  • DWI: diffusion restriction with low apparent diffusion coefficients values secondary to high cellularity, which could mimic malignancy

The differential diagnosis of nasal masses includes granulomatous and neoplastic diseases which can mimic rhinoscleroma, 5

Granulomatous diseases include:

Neoplasms: such as (lymphoma and sinonasal carcinoma). Expansion of the nasal cavities, scalloping of the sinus wall, lack of bone destruction and hyperintensity on T1 help to differentiate rhinoscleroma from nasal malignancies

Differential diagnosis for tracheal subglottic narrowing include:

Article information

rID: 18831
Synonyms or Alternate Spellings:
  • Klebsiella rhinoscleromatis

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Cases and figures

  • Case 1: CT
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  • Case 1: MRI
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