Last revised by Yuranga Weerakkody on 2 Nov 2022

Rhinoscleroma is a chronic granulomatous infection involving the upper respiratory tract due to Klebsiella rhinoscleromatis. It initially involves the nasal mucosa but it may progress to involve any part of the upper respiratory tract. Untreated rhinoscleroma slowly progresses over many years 1.

Patients most often present with nasal obstruction. Other nonspecific symptoms are often encountered such as epistaxis, rhinorrhea, dysphagia, stridor, and dysphonia.

Patients with rhinoscleroma are usually between 10 to 30 years old. It is endemic in Central America, Egypt, tropical Africa, India, and Indonesia 3.

  • poor hygiene

  • prolonged close contact

  • malnutrition

Characteristic radiological feature of rhinoscleroma is the presence of nasal mass with the following criteria 4,5:

  • bilateral or unilateral expansile nasal masses, lesions are usually homogeneous, hyperdense and non-enhancing

  • masses usually extend through the nasal nares anteriorly and into the adjacent paranasal sinuses

  • lesions line the sinus wall causing bone sclerosis, bone thinning (pressure atrophy) or it may absorb it with extrasinus extension

  • no bone destruction which helps to differentiate it from malignant lesions

  • in long standing cases, rhinoscleroma may extend to involve other parts of the upper respiratory tract:

    • such as pharynx with nodular infiltration of the oropharynx, tonsillar bed, soft and hard palate

    • may also show laryngotracheal involvement, the usual site of laryngeal involvement is the glottic–subglottic region showing concentric narrowing of the airway, thickening of the tracheal wall and nodular thickening of the tracheal mucosa 5

Lesions demonstrate characteristic signal intensity 4,5:

  • T1: mild to marked high signal intensity secondary to increased protein content within Mikulicz cells and Russell bodies

  • T2: hyperintense due to its high cellular component with hypointense foci of fibrosis

  • T1 C+ (Gd): inhomogeneous contrast enhancement secondary to areas of fibrosis

  • DWI: diffusion restriction with low apparent diffusion coefficients values secondary to high cellularity, which could mimic malignancy

The differential diagnosis of nasal masses includes granulomatous and neoplastic diseases which may mimic rhinoscleroma 5.

Granulomatous diseases include:

Neoplasms: such as lymphoma and sinonasal carcinoma

Findings helping differentiate rhinoscleroma from nasal malignancy:

  • expansion of the nasal cavities

  • scalloping of the sinus wall

  • lack of bone destruction

  • hyperintensity on T1

Differential diagnosis for tracheal narrowing includes:

ADVERTISEMENT: Supporters see fewer/no ads

Cases and figures

  • Case 1: CT
    Drag here to reorder.
  • Case 1: MRI
    Drag here to reorder.
  • Updating… Please wait.

     Unable to process the form. Check for errors and try again.

     Thank you for updating your details.