Richter tranformation

Richter transformation is defined as a diffuse large cell lymphoma, occurring by transformation of chronic lymphocytic leukemia (CLL).

It may be observed is approximately 5-10% of patient's with chronic lymphocytic leukaemia 5.

Patient's may present with an aggressive disease course with rapidly enlarging lymph nodes, hepatosplenomegaly, and elevated serum lactate dehydrogenase (LDH) levels.

The nodal disease can potentially occur anywhere in the body. The disease can also present as distinct mass like lesions 1.

Associations

Epstein Barr virus infection:

  • has been shown to associated in smal proportion of patients.

It was first described by M N Richter in 1928 4.

On pathology the biopsy results can mimic small lymphocytic lymphoma

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Article Information

rID: 39619
System: Chest
Synonyms or Alternate Spellings:
  • Richter transformation of chronic lymphocytic leukaemia
  • Richter tranformation of CLL
  • Richter's syndrome
  • Richter syndrome
  • Richter's tranformation
  • Richter's tranformation of CLL
  • Richter's transformation of chronic lymphocytic leukaemia
  • Richter syndrome (RS)

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