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Rokitansky-Aschoff sinuses are diverticula of the gallbladder wall which may be microscopic or macroscopic. Histologically, they are outpouchings of gallbladder mucosa that sit within the gallbladder muscle layer.
They are not themselves considered abnormal but may be associated with cholecystitis and adenomyomatosis. Additionally, Rokitansky-Aschoff sinuses have been known to mimic gallbladder adenocarcinoma, however, are generally incidental findings 4.
History and etymology
The Rokitansky-Aschoff sinus is named after the two pathologists who initially discovered them:
- Baron Karl Freiherr von Rokitansky (1804-1878), Czech pathologist in Vienna, Austria 5
Karl Albert Ludwig Aschoff (1866-1942), pathologist in Bonn, Germany 5
- described the Aschoff body of rheumatic heart disease 5
- invented the term "endothelial system" 5
- 1. Yoshimitsu K, Honda H, Jimi M et-al. MR diagnosis of adenomyomatosis of the gallbladder and differentiation from gallbladder carcinoma: importance of showing Rokitansky-Aschoff sinuses. AJR Am J Roentgenol. 1999;172 (6): 1535-40. AJR Am J Roentgenol (abstract) - Pubmed citation
- 2. Van breda vriesman AC, Engelbrecht MR, Smithuis RH et-al. Diffuse gallbladder wall thickening: differential diagnosis. AJR Am J Roentgenol. 2007;188 (2): 495-501. doi:10.2214/AJR.05.1712 - Pubmed citation
- 3. Kanne JP, Rohrmann CA, Lichtenstein JE. Eponyms in radiology of the digestive tract: historical perspectives and imaging appearances. Part 2. Liver, biliary system, pancreas, peritoneum, and systemic disease. Radiographics. 2006;26 (2): 465-80. doi:10.1148/rg.262055130 - Pubmed citation
- 4. Dorantes-Heredia R, Chablé-Montero F, Henson DE, Albores-Saavedra J. Rokitansky-Aschoff sinuses mimicking adenocarcinoma of the gallbladder: a study of 8 cases. (2013) The American journal of surgical pathology. 37 (8): 1269-74. doi:10.1097/PAS.0b013e318286bd39 - Pubmed
- 5. Anton Sebastian. A Dictionary of the History of Medicine. (1999) ISBN: 9781850700210