Romana sign (Chagas disease)

A.Prof Frank Gaillard et al.

Romana sign, also known as chagoma, refers to periorbital swelling, palpebral oedema and conjunctivitis seen 1-2 weeks following infection with Trypanosoma cruzi (causative agent in the Chagas disease). 

Romana sign is associated with ipsilateral regional lymphadenopathy. 

History and etymology

It is named after Cecilio Félix Romana, Argentinian researcher (1899 - 1997), who first described the phenomenon.

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Article information

rID: 5605
System: Head & Neck
Section: Signs
Tag: refs
Synonyms or Alternate Spellings:
  • Romana sign

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