Romana sign (Chagas disease)

Romana sign, also known as chagoma, refers to periorbital swelling, palpebral edema and conjunctivitis seen 1-2 weeks following infection with Trypanosoma cruzi (causative agent in Chagas disease). 

Romana sign is associated with ipsilateral regional lymphadenopathy. 

History and etymology

It is named after Cecilio Félix Romana (1899 - 1997), Argentinian physician, who first described the phenomenon.

Article information

rID: 5605
System: Head & Neck
Section: Signs
Tag: refs
Synonyms or Alternate Spellings:
  • Romana sign
  • Chagoma

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Cases and figures

  • Chagoma (photograph)
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