Romana sign (Chagas disease)
Romana sign, also known as chagoma, refers to periorbital swelling, palpebral oedema and conjunctivitis seen 1-2 weeks following infection with Trypanosoma cruzi (causative agent in the Chagas disease).
Romana sign is associated with ipsilateral regional lymphadenopathy.
History and etymology
It is named after Cecilio Félix Romana, Argentinian researcher (1899 - 1997), who first described the phenomenon.