ROS1 mutation

Last revised by Daniel J Bell on 6 Aug 2019

The ROS1 mutation is a mutation occurring in the ROS1 oncogene on chromosome 6 resulting in a defective receptor tyrosine kinase which has structural similarity to the anaplastic lymphoma kinase (ALK) protein.

It is thought to be present in several cancers of the subtype non-small cell lung cancers (NSCLC) (1-2%).

Useful for assessing appropriateness of treatment agents such as crizotinib.

It is thought to have been first identified by Rikova et al 3.

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