Citation, DOI, disclosures and article data
At the time the article was created Yuranga Weerakkody had no recorded disclosures.View Yuranga Weerakkody's current disclosures
At the time the article was last revised Daniel J Bell had no recorded disclosures.View Daniel J Bell's current disclosures
The ROS1 mutation is a mutation occurring in the ROS1 oncogene on chromosome 6 resulting in a defective receptor tyrosine kinase which has structural similarity to the anaplastic lymphoma kinase (ALK) protein.
It is thought to be present in several cancers of the subtype non-small cell lung cancers (NSCLC) (1-2%).
Useful for assessing appropriateness of treatment agents such as crizotinib.
History and etymology
It is thought to have been first identified by Rikova et al 3.
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