Rosenthal fibers

Dr Henry Knipe and Dr Yuranga Weerakkody et al.

Rosenthal fibers are astrocytic cytoplasmic inclusions, typically found in areas of longstanding gliosis. These elongated or "corkscrew" structures occur within astrocytic processes and are brightly eosinophilic (stain bright pink on the H&E stain) 1-3. They represent astrocytic processes swollen with glial filaments and amorphous granular material 3

They can be seen in a number conditions, all of which have prominent fibrillary gliosis. Such conditions include 1,3

Share article

Article information

rID: 9211
Section: Pathology
Synonyms or Alternate Spellings:

Support Radiopaedia and see fewer ads

Cases and figures

  • Figure 1: H&E stain 40x
    Drag here to reorder.
  • Figure 2
    Drag here to reorder.
  • Updating… Please wait.

     Unable to process the form. Check for errors and try again.

     Thank you for updating your details.