Citation, DOI & article data
S100 is a family of cytoplasmic calcium-binding proteins expressed in numerous cell lines which can be targeted by immunohistochemistry. Staining for S100 is helpful in characterizing a number of tumors, including malignant melanoma, glial tumors, neurogenic tumors (e.g. schwannomas and neurofibromas), mesenchymal tumors (e.g. chondromas, chondrosarcomas, liposarcomas, some osteogenic sarcomas) and some histiocytic tumors 1,2.
History and etymology
S100 is a contracture of 100% soluble in ammonium sulphate at neutral pH 3.
- 1. Schmitt FC, Bacchi CE. S-100 protein: is it useful as a tumour marker in diagnostic immunocytochemistry?. Histopathology. 15 (3): 281-8. Pubmed
- 2. Cochran AJ, Wen DR. S-100 protein as a marker for melanocytic and other tumours. Pathology. 17 (2): 340-5. Pubmed
- 3. Jose A. Plaza, Victor G Prieto. Applied Immunohistochemistry in the Evaluation of Skin Neoplasms. ISBN: 9783319305905